A01 Naokazu Kano

Naokazu Kano

Participating A01


Department of Chemistry, Gakushuin University





Research Project

Creation of Coordination-Asymmetric and Functional Molecules Based on a Bond between Highly Coordinated Main Group Elements


Several bonds between the second-row elements work as functional groups in organic chemistry. Instead of such conventional bonds, we create new chemical bonds between two different elements in a highly coordinated state or hypervalent state. The coordination number of the central main-group-element atoms in the new bonds are oncreased, and formation of many potential diastereomers are expected. We develop selective and efficient synthetic methods for some specific isomers among them. We choose pentacoordinated silicon or phosphorus, the third-row elements, for one of the element which forms the bond, and boron or aluminum, the group 13 elements, for the counterpart. Such the compounds bearing the new bond should be unique Lewis acids which have a hypervalent moiety bound to the Lewis acid center. They are expected to be functional coordination-asymmetric molecules.

Research Areas

Main Group Chemistry, Structural Organic Chemistry, Organic Reactions


Main Group Element, Chemical Bond, Functional Group, Highly Coordinated Compound, Hypervalent Compound


[9] Photocatalytic Giese‐Type Reaction with Alkylsilicates Bearing C,O‐Bidentate Ligands,
Tatsuya Morofuji; Yu Matsui; Misa Ohno; Gun Ikarashi; Naokazu Kano, Chem. Eur. J., , 2021
DOI: 10.1002/chem.202005300.


[8] Synthesis, structure and properties of a boron-substituted phosphorane bearing N,O-bidentate ligands,
Nathan J. O’Brien; Yoichiro Koda; Hiroaki Maeda; Naokazu Kano, Polyhedron, 185, 114841, 2020
DOI: 10.1016/j.poly.2020.114841.
[7] Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A,
Alexander A. Vinogradov; Morito Shimomura; Naokazu Kano; Yuki Goto; Hiroyasu Onaka; Hiroaki Suga, J. Am. Chem. Soc., 142, 32, 13886 – 13897, 2020
DOI: 10.1021/jacs.0c05541.
[6] Arylation of aryllithiums with S-arylphenothiazinium ions for biaryl synthesis,
Tatsuya Morofuji; Tatsuki Yoshida; Ryosuke Tsutsumi; Masahiro Yamanaka; Naokazu Kano, Chem. Commun., 56, 90, 13995 – 13998, 2020
DOI: 10.1039/D0CC05830K.
[5] Synthesis, Structure and Reactivities of Pentacoordinated Phosphorus–Boron Bonded Compounds,
Nathan J. O’Brien; Naokazu Kano; Nizam Havare; Ryohei Uematsu; Romain Ramozzi; Keiji Morokuma, Eur. J. Inog. Chem., 2020, 20, 1995 – 2003, 2020
DOI: 10.1002/ejic.202000229.
[4] Photocatalytic C–H Amination of Aromatics Overcoming Redox Potential Limitations,
Tatsuya Morofuji; Gun Ikarashi; Naokazu Kano, Org. Lett., 22, 7, 2822 – 2827, 2020
DOI: 10.1021/acs.orglett.0c00822.
[3] Terminal-oxidant-free photocatalytic C–H alkylations of heteroarenes with alkylsilicates as alkyl radical precursors,
Gun Ikarashi; Tatsuya Morofuji; Naokazu Kano, Chem. Commun., 56, 69, 10006 – 10009, 2020
DOI: 10.1039/d0cc03286g.


[2] Connecting a carbonyl and a π-conjugated group through a p-phenylene linker by (5+1) benzene ring formation,
Tatsuya Morofuji; Hanae Kinoshita; Naokazu Kano, Chem. Commun., 55, 59, 8575 – 8578, 2019
DOI: 10.1039/C9CC04012A.


[1] Trihydroborates and Dihydroboranes Bearing a Pentacoordinated Phosphorus Atom: Double Ring Expansion To Balance the Coordination States,
Naokazu Kano; Nathan J. O’Brien; Ryohei Uematsu; Romain Ramozzi; Keiji Morokuma, Angew. Chem. Int. Ed., 56, 21, 5882 – 5885, 2017