A01 Shigehisa Akine

Shigehisa Akine

A01 Planning


Graduate School of Natural Science and Technology, Kanazawa University





Research Project

Dynamic Conversion of Coordination Chirality and Time Profile Control


Yoko Sakata (Assistant Professor, Graduate School of Natural Science and Technology, Kanazawa University)


We develop a new type of dynamic conversion systems in which the “coordination chirality” can be changed according to external stimuli. We use tris(salen)-based single helical complexes and cage-like triple helical complexes as the basic scaffold for the dynamic systems. We investigate the response speed and profiles in the coordination chirality after stimulation. For example, we construct a system in which the coordination chirality can be controlled by recognition of metal ions and organic molecules or by changes in the pH, potential, temperature, pressure, etc. In addition, we make a relay system in which chemical information is transferred for two or more steps. We are also planning to investigate the dynamic conversion of the coordination chirality on solid surfaces by using the helical complexes immobilized onto the solid surfaces.

Research Areas

coordination chemistry, supramolecular chemistry, host-guest chemistry


helical complex, cage-like complex, macrocyclic complex, dynamic structural conversion, chirality inversion


[26] A chiral spirobifluorene-based bis(salen) zinc(II) receptor towards highly enantioselective binding of chiral carboxylates,
Sk Asif Ikbal; Yoko Sakata; Shigehisa Akine, Dalton Trans., 50, 12, 4119 – 4123, 2021
DOI: 10.1039/d1dt00218j.
[25] Guest Recognition Control Accompanied by Stepwise Gate-Closing and Opening of a Macrocyclic Metallohost,
Sakata, Y.; Okada, M.; Akine, S., Chem. Eur. J., 27, 7, 2284 – 2288, 2021
DOI: 10.1002/chem.202004487.


[24] Control of Guest Binding Kinetics in Macrocycles and Molecular Cages,
Akine, S.; Sakata, Y., Chem. Lett., 49, 4, 428 – 441, 2020
DOI: 10.1246/cl.200017.
[23] Non-Covalent Interactions Enable the Length-Controlled Generation of Discrete Tubes Capable of Guest Exchange,
Fa, S.; Sakata, Y.; Akine, S.; Ogoshi, T. , Angew. Chem. Int. Ed., 59, 24, 9309 – 9313, 2020
DOI: 10.1002/anie.201916515.
[22] Post-Metalation Modification of a Macrocyclic Dicobalt(III) Metallohost by Site-Selective Ligand Exchange for Guest Recognition Control,
Sakata, Y.; Okada, M.; Tamiya, M.; Akine, S., Chem. Eur. J., 26, 34, 7595 – 7601, 2020
DOI: 10.1002/chem.202001072.
[21] Vapoluminescence Behavior Triggered by Crystal-State Complexation between Host Crystals and Guest Vapors Exhibiting No Visible Fluorescence,
Ogoshi, T.; Hamada, Y.; Sueto, R.; Kojima, R.; Sakakibara, F.; Nagata, Y.; Sakata, Y.; Akine, S.; Ono, T.; Kakuta, T.; Yamagishi, T.-a., Cryst. Growth. Des., 20, 11, 7087 – 7092, 2020
DOI: 10.1021/acs.cgd.0c00982.
[20] Efficient formation of [3]pseudorotaxane based on cooperative complexation of dibenzo-24-crown-8 with diphenylviologen axle,
Sakata, Y.; Ogura, T.; Akine, S., Chem. Commun., 56, 62, 8735 – 8738, 2020
DOI: 10.1039/D0CC03131C.
[19] Macrocyclic dimer of Fc(NHC(O)PPh2-AuCl)2 induced by aurophilic interactions, and chirality induction into Fc core,
Matsutani, T.; Itazaki, M.; Akine, S.; Moriuchi, T., J. Organomet. Chem., 912, 121182, 2020
DOI: 10.1016/j.jorganchem.2020.121182.


[18] ON/OFF Control of the Flipping Motion of Diuranyl Bis(Salophen) Macrocycle by Extremely Strong Binding with Fluoride Ion,
Cametti, M.; Sakata, Y.; Martí-Rujas, J.; Akine, S., Inorg. Chem., 58, 21, 14871 – 14875, 2019
DOI: 10.1021/acs.inorgchem.9b02587.
[17] Switching of Recognition First and Reaction First Mechanisms in Host–Guest Binding Associated with Chemical Reactions,
Yoko Sakata; Munehiro Tamiya; Masahiro Okada; Shigehisa Akine, J. Am. Chem. Soc., 141, 39, 15597 – 15604, 2019
DOI: 10.1021/jacs.9b06926.
[16] Functionalized metallonanobelt derivatives having quinoxaline scaffold prepared from a common precursor,
Yoko Sakata; Yoshiki Furukawa; Shigehisa Akine, Tetrahedron Lett., 60, 31, 2049 – 2053, 2019
DOI: 10.1016/j.tetlet.2019.06.057.
[15] Ligand Exchange Strategy for Tuning of Helicity Inversion Speeds of Dynamic Helical Tri(saloph) Metallocryptands,
Yoko Sakata; Shunsuke Chiba; Masato Miyashita; Tatsuya Nabeshima; Shigehisa Akine, Chem. Eur. J., 25, 12, 2962 – 2966, 2019
DOI: 10.1002/chem.201805799.
[14] Host–Guest Complexation Using Pillar[5]arene Crystals: Crystal-Structure Dependent Uptake, Release, and Molecular Dynamics of an Alkane Guest,
Tomoki Ogoshi; Yukie Hamada; Sueto Ryuta; Yoko Sakata; Shigehisa Akine; Adhitya Mangala Putra Moeljadi; Hajime Hirao; Takahiro Kakuta; Tada-aki Yamagishi; Motohiro Mizuno, Chem. Eur. J., 25, 10, 2497 – 2502, 2019
DOI: 10.1002/chem.201805733.
[13] Molecular weight fractionation by confinement of polymer in one-dimensional pillar[5]arene channels,
Tomoki Ogoshi; Ryuta Sueto; Masafumi Yagyu; Ryosuke Kojima; Takahiro Kakuta; Tada-aki Yamagishi; Kazuki Doitomi; Anil Kumar Tummanapelli; Hajime Hirao; Yoko Sakata; Shigehisa Akine; Motohiro Mizuno, Nat. Commun., 10, 479, 1 – 8, 2019
DOI: 10.1038/s41467-019-08372-1.
[12] A Closed Metallomolecular Cage that can Open its Aperture by Disulfide Exchange,
Shigehisa Akine; Masato Miyashita; Tatsuya Nabeshima, Chem. Eur. J., 25, 6, 1432 – 1435, 2019
DOI: 10.1002/chem.201805359.


[11] Dynamic Helicity Control of Oligo(salamo)-Based Metal Helicates,
Akine, S., Inorganics, 6, 3, 1 – 19, 2018
DOI: 10.3390/inorganics6030080.
[10] Metallonanobelt: A Kinetically Stable Shape-Persistent Molecular Belt Prepared by Reversible Self-Assembly Processes,
Yoko Sakata; Ryoichi Yamamoto; Daiki Saito; Yuko Tamura; Keisuke Maruyama; Tomoki Ogoshi; Shigehisa Akine, Inorg. Chem., 57, 24, 15500 – 15506, 2018
DOI: 10.1021/acs.inorgchem.8b02804.
[9] Separation of Linear and Branched Alkanes Using Host–Guest Complexation of Cyclic and Branched Alkane Vapors by Crystal State Pillar[6]arene,
Tomoki Ogoshi; Kazuki Saito; Ryuta Sueto; Ryosuke Kojima; Yukie Hamada; Shigehisa Akine; Adhitya Mangala Putra Moeljadi; Hajime Hirao; Takahiro Kakuta; Tada‐aki Yamagishi, Angew. Chem. Int. Ed., 57, 6, 1592 – 1595, 2018
DOI: 10.1002/anie.201711575.
[8] A novel graphite-like stacking structure in a discrete molecule and its molecular recognition behavior,
Shigehisa Akine; Onuma Takahiro; Tatsuya Nabeshima, New J. Chem., 42, 9369 – 9372, 2018
DOI: 10.1039/c8nj01315b.


[7] Alkane-length sorting using activated pillar[5]arene crystals,
Tomoki Ogoshi; Ryuta Sueto; Yukie Hamada; Kazuki Doitomi; Hajime Hirao; Yoko Sakata; Shigehisa Akine; Takahiro Kakuta; Tada-aki Yamagishi, Chem. Commun., 53, 61, 8577 – 8580, 2017
DOI: 10.1039/c7cc04454b.
[6] New mechanistic insights into intramolecular aromatic ligand hydroxylation and benzyl alcohol oxidation initiated by the well-defined (µ-peroxo)diiron(III) complex,
Mio Sekino; Hideki Furutachi; Rina Tojo; Ayumi Hishi; Hanako Kajikawa; Takatoshi Suzuki; Kaito Suzuki; Shuhei Fujinami; Shigehisa Akine; Yoko Sakata; Takehiro Ohta; Shinya Hayami; Masatatsu Suzuki, Chem. Commun., 53, 63, 8838 – 8841, 2017
DOI: 10.1039/c7cc04382a.
[5] Anion-capped Metallohost Allows Extremely Slow Guest Uptake and On-demand Acceleration of Guest Exchange,
Yoko Sakata; Chiho Murata; Shigehisa Akine, Nat. Commun., 8, 16005, 1 – 7, 2017
DOI: 10.1038/ncomms16005.
[4] Two-Step Modulation of Ion Recognition Using a Bis(saloph)-Macrocyclic Host Having a 24-Crown-8-Like Cavity,
Yoko Sakata; Seiya Kobayashi; Shigehisa Akine, Chem. Commun., 53, 47, 6363 – 6366, 2017
DOI: 10.1039/C7CC02641B.
[3] A Metallo-Molecular Cage That Can Close the Apertures with Coordination Bonds,
Shigehisa Akine; Masato Miyashita; Tatsuya Nabeshima, J. Am. Chem. Soc., 139, 13, 4631 – 4634, 2017
DOI: 10.1021/jacs.7b00840.
[2] Electronic Perturbation of Supramolecular Conjugates of Porphyrins and Phthalocyanines,
Nozomi Mihara; Yasuyuki Yamada; Shigehisa Akine; Kunihisa Sugimoto; Kentaro Tanaka, Chem. Commun., 53, 14, 2230 – 2232, 2017
DOI: 10.1039/c6cc09590a.


[1] Lanthanide Contraction for Helicity Fine-Tuning and Helix-Winding Control of Single-Helical Metal Complexes,
Shiho Sairenji; Shigehisa Akine; Tatsuya Nabeshima, Dalton Trans., 45, 38, 14902 – 14906, 2016
DOI: 10.1039/C6DT02635D.