A01 Takumi Yamaguchi

Takumi Yamaguchi

Participating A01


Japan Advanced Institute of Science and Technology


Associate Professor



Research Project

Elucidation and control of asymmetric- hierarchical structures derived from the interactions between carbohydrates


We focus on carbohydrates as molecules that provide asymmetric coordination sphere.  The biological functions of carbohydrates represented by cell adhesion are often exerted through the interactions between divalent cations and oligosaccharides, as well as their clustering. Selective- heterophilic complexation of carbohydrates is also an important factor for living system. In this study, we aim to investigate coordination asymmetry underlying the expression mechanism of biological functions of carbohydrates, and to provide design principles for material creation.

By using solution NMR techniques, we attempt to address the structural characterization of metal ion-induced carbohydrate complexes to reveal the physicochemical basis of the interactions between oligosaccharides. Furthermore, we will design and develop glycoclusters for realizing molecular system with cell-like mutual recognition ability and motility.

Research Areas

Glyco-Engineering, Biofunctional Chemistry, Biophysics


Carbohydrate, Glycolipid, NMR, Paramagnetic Effect


[2] Remodeling of the oligosaccharide conformational space in the prebound state to improve lectin-binding affinity,
Tatsuya Suzuki; Saeko Yanaka; Tokio Watanabe; Gengwei Yan; Tadashi Satoh; Hirokazu Yagi; Takumi Yamaguchi; Koichi Kato, Biochemistry, 59, 34, 3180 – 3185, 2020
DOI: 10.1021/acs.biochem.9b00594.
[1] Solid-state 17O NMR analysis of synthetically 17O-enriched D-glucosamine,
KazuhikoYamada; Yoshiki Yamaguchi; Yoshinori Uekusa; Kazumasa Aoki; Ichio Shimada; Takumi Yamaguchi; Koichi Kato, Chem. Phys. Lett., 749, 137455, 2020
DOI: 10.1016/j.cplett.2020.137455.