A01 Yuji Mikata

Yuji Mikata

Participating A01


  1. Department of Chemistry, Biology, and Environmental Science, Faculty of Science, Nara Women’s University
  2. KYOUSEI Science Center for Life and Nature, Nara Women’s University





Research Project

Stabilization of “Asymmetric Oxygen Atom” with (Iso)quinoline-based Ligands


Development of chiral compound has been continuous interest in various fields. Many chiral compounds exhibit asymmetric carbon atoms, whereas sulfur (sulfoxide), nitrogen, phosphine, and other elements are also reported to serve as a chiral center. In this research proposal, we are going to demonstrate the possibility of effective oxygen chirality utilizing metal-coordinated oxygen atom. Usually, lone pair in heteroatom such as nitrogen inverts quickly to racemize the chiral center. However, this inversion can be substantially retarded by the metal ion coordination to the lone pair. As an initial stage of this research, we have demonstrated that the achiral ligand (HLCOO) generates two diastereomeric one-dimensional coordination polymers based on the “oxygen chirality” that differentiates homo- and heterochiral intermolecular interactions.

Research Areas

Bioinorganic Chemistry, Organic Chemistry, Coordination Chemistry


Isoquinoline, Quinoline, Asymmetric Oxygen Atom, Enantiomer, Optical Resolution


[5] N,N,N’,N’-Tetrakis(3-isoquinolylmethyl)-2,6-lutidylenediamine (3-isoTQLN): A Fluorescent Zn2+/Cd2+ Dual Sensor as a Hybrid of 2-Quinolyl/1-Isoquionolyl Counterparts TQLN/1-isoTQLN,
Yuji Mikata; Ayaka Takekoshi; Minori Kaneda; Shizuka Yonemura; Yuri Aono; Arimasa Matsumoto; Hideo Konno; Shawn C. Burdette, Eur. J. Inog. Chem., in press, 2021
DOI: 10.1002/ejic.202001171.
[4] Structure and electrochemical properties of (µ-O)2Mn2(III,III) and (µ-O)2Mn2(III,IV) complexes supported by pyridine-, quinoline-, isoquinoline- and quinoxaline-based tetranitrogen ligands,
Yuji Mikata; Yasuko Kuroda; Kyoko Naito; Kana Murakami; Chihiro Yamamoto; Shoko Yabe; Shizuka Yonemura; Arimasa Matsumoto; Hajime Katano, Dalton Trans., 50, 12, 4133 – 4144, 2021
DOI: 10.1039/d1dt00184a.


[3] Conversion of (µ-OH)2Mn2(II,II) Complex to (µ-O)2Mn2(III,III) Core Supported by a Quinoxaline-Based Tetranitrogen Ligand,
Yuji Mikata; Kana Murakami; Ayaka Ochi; Fumie Nakagaki; Kyoko Naito; Arimasa Matsumoto; Ryoji Mitsuhashi; Masahiro Mikuriya, Inorg. Chim. Acta, 509, 119688, 2020
DOI: 10.1016/j.ica.2020.119688.
[2] A Tetrakisquinoline Analog of Calcium Indicator Quin2 for Fluorescence Detection of Cd2+,
Yuji Mikata; Minori Kaneda; Marin Tanaka; Satoshi Iwatsuki; Hideo Konno; Arimasa Matsumoto, Eur. J. Inog. Chem., 9, 757 – 763, 2020
DOI: 10.1002/ejic.201901323.
[1] Switching of Fluorescent Zn/Cd Selectivity in N,N,N’,N’-Tetrakis(6-methoxy-2-quinolylmethyl)-1,2-diphenylethylenediamine (6-MeOTQPh2EN) by One Asymmetric Carbon Atom Inversion,
Yuji Mikata; Kana Nozaki; Marin Tanaka; Hideo Konno; Arimasa Matsumoto; Masaya Kawamura; Shin-ichiro Sato, Inorg. Chem., 59, 8, 5313 – 5324, 2020
DOI: 10.1021/acs.inorgchem.9b03304.